MOTS-c
Also known as: MOTS-c, Mitochondrial-derived peptide
Pricing — All Vial Sizes
| Vial Size | Kit Price | Per Vial | Per mg | Stock |
|---|---|---|---|---|
| 5 mg← selected | $80 | $8.00 | $1.60/mg | ○ Out of Stock |
| 10 mg | $70 | $7.00 | $0.70/mg | ● In Stock |
| 40 mg | $210 | $21.00 | $0.53/mg | ○ Out of Stock |
Last changed: 4h ago
Summary
MOTS-c is a 16-amino acid peptide encoded within the mitochondrial genome (12S rRNA). It acts as a retrograde signal from mitochondria to the nucleus, regulating metabolic homeostasis. Research in rodents shows exercise-mimicking metabolic effects, improved insulin sensitivity, and increased longevity.
MOTS-c is unusual — it's one of the only known signaling molecules encoded in mitochondrial DNA (your cellular power plants) rather than the nuclear genome. When cells are stressed metabolically, MOTS-c is released as a signal to the rest of the cell and body to ramp up glucose uptake and fat burning — mimicking what exercise does. Old mice given MOTS-c showed significantly improved metabolic health.
Mechanism of Action↓
Activates AMPK (AMP-activated protein kinase) and inhibits the folate cycle and de novo purine synthesis. Translocates to the nucleus during metabolic stress where it regulates gene expression. Increases glucose uptake in muscle, improves mitochondrial function.
Half-life: ~0.5–2 hours (estimated)
Research Dosing Ranges↓
5–10 mg per week
2–3× weekly subcutaneous injection
Animal studies use 5 mg/kg doses; human equivalent substantially lower. Very early stage human research.
Reconstitution Guidance↓
BAC water: 1 mL
Resulting concentration: mg/mL depends on vial size
Standard BAC water reconstitution.
Storage & Stability↓
Refrigerate. Reconstituted: use within 28 days.
Known Side Effects / Contraindications↓
Very limited human data. Well tolerated in animal studies.
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Reconstitution Calculator
Concentration
1.67 mg/mL
Volume per dose
150.0 µL
U-100 units
15.0 units
Doses per vial
20.0
Cost per dose
$0.40(based on kit price)
Show math
Concentration: 5 mg ÷ 3 mL = 1.67 mg/mL (1667 µg/mL)
Dose needed: 250 µg = 0.2500 mg
Volume per dose: 0.2500 mg ÷ 1.67 mg/mL = 0.1500 mL
On U-100 syringe: 150.0 µL = 15.0 units
Total doses in vial: 5 mg ÷ 0.2500 mg = 20.0 doses
⚠ Research Reference Only
All dosage information, mechanisms, and research data on this site are provided for educational and research reference purposes only. This is not medical advice. These compounds are not approved for human use or consumption. Always consult a licensed medical professional and comply with your local regulations.