Melanotan I
Also known as: Afamelanotide, α-MSH analogue
Pricing — All Vial Sizes
| Vial Size | Kit Price | Per Vial | Per mg | Stock |
|---|---|---|---|---|
| 10 mg← selected | $70 | $7.00 | $0.70/mg | ○ Out of Stock |
| 110 mg | $75 | $7.50 | $0.07/mg | ○ Out of Stock |
Last changed: 4h ago
Summary
Melanotan I (afamelanotide) is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH). It preferentially activates MC1R on melanocytes to stimulate melanin production (tanning) independent of UV exposure. An approved formulation (Scenesse) is used for erythropoietic protoporphyria photoprotection in some countries.
MT1 triggers your skin cells to produce melanin — the pigment that makes you tan — without needing UV exposure first. It's selective enough to mainly affect the skin rather than crossing into the brain, so it doesn't produce the libido and appetite effects of MT2. An implant version (Scenesse) is approved in Europe for people with a genetic condition that makes sunlight extremely painful.
Mechanism of Action↓
Selective MC1R agonist. Stimulates eumelanin (brown/black) synthesis in melanocytes via cAMP/PKA pathway. Does not cross the blood-brain barrier as readily as MT2, resulting in fewer CNS effects.
Half-life: ~3.5 hours (implant: sustained over weeks)
Research Dosing Ranges↓
0.5–1 mg per injection
As needed (not for daily use); every 2–3 days maximum
Begin at 0.5 mg to assess response. Less CNS activity than MT2 due to lower BBB penetration.
Reconstitution Guidance↓
BAC water: 3 mL
Resulting concentration: mg/mL depends on vial size
Add 3 mL BAC water. Standard reconstitution.
Storage & Stability↓
Refrigerate. Protect from light. Reconstituted: use within 28 days.
Known Side Effects / Contraindications↓
Skin darkening, nausea, facial flushing. Less potent for libido effects than MT2.
Price History
Showing history for the 10 mg vial.
Change History
Reconstitution Calculator
Concentration
3.33 mg/mL
Volume per dose
75.0 µL
U-100 units
7.5 units
Doses per vial
40.0
Cost per dose
$0.17(based on kit price)
Show math
Concentration: 10 mg ÷ 3 mL = 3.33 mg/mL (3333 µg/mL)
Dose needed: 250 µg = 0.2500 mg
Volume per dose: 0.2500 mg ÷ 3.33 mg/mL = 0.0750 mL
On U-100 syringe: 75.0 µL = 7.5 units
Total doses in vial: 10 mg ÷ 0.2500 mg = 40.0 doses
⚠ Research Reference Only
All dosage information, mechanisms, and research data on this site are provided for educational and research reference purposes only. This is not medical advice. These compounds are not approved for human use or consumption. Always consult a licensed medical professional and comply with your local regulations.