Mazdutide
Also known as: IBI362, GLP-1/glucagon dual agonist
Pricing — All Vial Sizes
| Vial Size | Kit Price | Per Vial | Per mg | Stock |
|---|---|---|---|---|
| 10 mg← selected | $170 | $17.00 | $1.70/mg | ● In Stock |
Last changed: May 26
Summary
Mazdutide (IBI362) is an investigational GLP-1 and glucagon receptor dual agonist developed by Innovent Biologics (China). Phase 3 data showed up to ~15% body weight reduction. It is distinct from tirzepatide (GLP-1/GIP) — it pairs GLP-1 with glucagon, not GIP, adding an energy expenditure component via glucagon receptor activation.
Similar to tirzepatide but with a different 'second partner.' Tirzepatide pairs GLP-1 with GIP; mazdutide pairs GLP-1 with glucagon. The glucagon part is what makes it interesting — glucagon normally raises blood sugar, but in combination with GLP-1 the blood sugar effect is neutralized while glucagon's metabolic boost (increased calorie burning) is preserved. Mainly approved and studied in China.
Mechanism of Action↓
GLP-1 receptor agonism mediates satiety, slows gastric emptying, and provides incretin insulin secretion. Glucagon receptor (GCGR) co-agonism increases hepatic glucose output, thermogenesis, and lipolysis — complementary to GLP-1 with net metabolic benefit at moderate GCGR activation. The dual mechanism drives greater energy expenditure than GLP-1 mono-agonists.
Half-life: ~7 days (once-weekly dosing in trials)
Research Dosing Ranges↓
2 mg → 3 mg → 4.5 mg → 6 mg per week
Once weekly subcutaneous injection (titration)
Phase 3 titration: start at 2 mg/week × 4 weeks, escalate to 3, 4.5, up to 6 mg/week. Research doses up to 9–10 mg/week studied. Approved in China at 3–9 mg range. GI tolerability drives titration pace.
Reconstitution Guidance↓
BAC water: 1 mL
Resulting concentration: mg/mL depends on vial size
Standard BAC water reconstitution.
Storage & Stability↓
Refrigerate. Use within 28 days.
Known Side Effects / Contraindications↓
GI effects similar to GLP-1 class: nausea, vomiting, diarrhea.
Price History
Change History
Reconstitution Calculator
Concentration
3.33 mg/mL
Volume per dose
75.0 µL
U-100 units
7.5 units
Doses per vial
40.0
Cost per dose
$0.42(based on kit price)
Show math
Concentration: 10 mg ÷ 3 mL = 3.33 mg/mL (3333 µg/mL)
Dose needed: 250 µg = 0.2500 mg
Volume per dose: 0.2500 mg ÷ 3.33 mg/mL = 0.0750 mL
On U-100 syringe: 75.0 µL = 7.5 units
Total doses in vial: 10 mg ÷ 0.2500 mg = 40.0 doses
⚠ Research Reference Only
All dosage information, mechanisms, and research data on this site are provided for educational and research reference purposes only. This is not medical advice. These compounds are not approved for human use or consumption. Always consult a licensed medical professional and comply with your local regulations.