Cagrilintide
Also known as: Long-acting amylin analogue, CagriSema component
Pricing — All Vial Sizes
| Vial Size | Kit Price | Per Vial | Per mg | Stock |
|---|---|---|---|---|
| 5 mg← selected | $95 | $9.50 | $1.90/mg | ○ Out of Stock |
| 10 mg | $155 | $15.50 | $1.55/mg | ○ Out of Stock |
Last changed: 3h ago
Summary
Cagrilintide is a long-acting acylated amylin analogue developed by Novo Nordisk. Amylin is co-secreted with insulin from pancreatic beta cells and complements glucose regulation. In combination with semaglutide (CagriSema), it showed additive weight loss of ~15–22% body weight in phase 3 trials; an NDA was filed with the FDA in 2025.
Amylin is a hormone your pancreas releases alongside insulin after every meal. It slows digestion, suppresses glucagon (a hormone that raises blood sugar), and signals the brain that you're full. Cagrilintide mimics amylin but lasts a full week. Combined with semaglutide (sold as CagriSema), it produced weight loss approaching what's seen with surgical interventions. Novo Nordisk is seeking FDA approval.
Mechanism of Action↓
Amylin receptor agonist (calcitonin receptor + RAMP heterodimer). Slows gastric emptying, suppresses postprandial glucagon, and induces satiety via area postrema and hypothalamic signaling. The fatty acid acyl chain on cagrilintide provides albumin binding, extending half-life to ~7 days for once-weekly dosing.
Half-life: ~7 days
Research Dosing Ranges↓
0.25 mg → 0.5 mg → 1.0 mg → 1.7 mg → 2.4 mg per week
Once weekly subcutaneous injection (titration schedule)
Standard titration: start at 0.25 mg/week × 4 weeks, then 0.5, 1.0, 1.7, up to 2.4 mg/week maintenance. GI tolerability drives titration pace. Phase 3 (REDEFINE) used 2.4 mg maintenance. Often paired with semaglutide 2.4 mg/week.
Reconstitution Guidance↓
BAC water: 1 mL
Resulting concentration: mg/mL depends on vial size
Standard BAC water reconstitution. Very low dose volumes required.
Storage & Stability↓
Refrigerate. Reconstituted: use within 28 days.
Known Side Effects / Contraindications↓
Nausea, decreased appetite, vomiting (amylin class effects). Generally well tolerated.
Price History
Showing history for the 5 mg vial.
Change History
Reconstitution Calculator
Concentration
1.67 mg/mL
Volume per dose
150.0 µL
U-100 units
15.0 units
Doses per vial
20.0
Cost per dose
$0.47(based on kit price)
Show math
Concentration: 5 mg ÷ 3 mL = 1.67 mg/mL (1667 µg/mL)
Dose needed: 250 µg = 0.2500 mg
Volume per dose: 0.2500 mg ÷ 1.67 mg/mL = 0.1500 mL
On U-100 syringe: 150.0 µL = 15.0 units
Total doses in vial: 5 mg ÷ 0.2500 mg = 20.0 doses
⚠ Research Reference Only
All dosage information, mechanisms, and research data on this site are provided for educational and research reference purposes only. This is not medical advice. These compounds are not approved for human use or consumption. Always consult a licensed medical professional and comply with your local regulations.