5-Amino-1MQ
Also known as: 5A1MQ, NNMT inhibitor
Pricing — All Vial Sizes
| Vial Size | Kit Price | Per Vial | Per mg | Stock |
|---|---|---|---|---|
| 10 mg← selected | $70 | $7.00 | $0.70/mg | ○ Out of Stock |
Last changed: May 26
Summary
5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in metabolic regulation and energy homeostasis. By inhibiting NNMT, it increases intracellular SAM (S-adenosyl methionine) and NAD+ levels. Animal studies show reduced fat cell size and improved metabolic markers.
Not technically a peptide — it's a small synthetic molecule that blocks an enzyme (NNMT) that essentially 'wastes' key cellular fuel. By blocking that waste, fat cells lose their ability to expand and store fat as efficiently. Animal studies showed significant reductions in fat cell size and weight. Very limited human data but growing interest in the metabolic longevity community.
Mechanism of Action↓
NNMT catalyzes methylation of nicotinamide to form 1-methylnicotinamide, consuming SAM. Inhibition raises SAM availability for methylation reactions and increases cellular NAD+ by reducing nicotinamide consumption via this pathway. In adipocytes this shifts metabolism toward fat oxidation.
Half-life: ~12–24 hours (estimated from rodent data)
Research Dosing Ranges↓
50–250 mg per day
Daily oral or subcutaneous
Most animal data uses oral administration. Human research protocols are limited.
Reconstitution Guidance↓
BAC water: 1 mL
Resulting concentration: mg/mL depends on vial size
Small molecule — reconstitute in DMSO or ethanol as co-solvent for aqueous suspensions if needed. Check solubility.
Storage & Stability↓
Room temp for powder. Reconstituted: use promptly.
Known Side Effects / Contraindications↓
Very limited human data. No significant toxicity in rodent studies at research doses.
Price History
Change History
Reconstitution Calculator
Concentration
3.33 mg/mL
Volume per dose
75.0 µL
U-100 units
7.5 units
Doses per vial
40.0
Cost per dose
$0.17(based on kit price)
Show math
Concentration: 10 mg ÷ 3 mL = 3.33 mg/mL (3333 µg/mL)
Dose needed: 250 µg = 0.2500 mg
Volume per dose: 0.2500 mg ÷ 3.33 mg/mL = 0.0750 mL
On U-100 syringe: 75.0 µL = 7.5 units
Total doses in vial: 10 mg ÷ 0.2500 mg = 40.0 doses
⚠ Research Reference Only
All dosage information, mechanisms, and research data on this site are provided for educational and research reference purposes only. This is not medical advice. These compounds are not approved for human use or consumption. Always consult a licensed medical professional and comply with your local regulations.